Apoptosis and Cadidiasis
Apoptosis is essential in the following processes:
- Remodeling during embrionary development, for example, the elimination of the interdigital areas
- Development of organs and systems. In order to establish the correct circuit of neural connections during development, the neurons that do not establish synaptic contacts must die by apoptosis. Also, in order to establish an adequate immune repertory, the T-lymphocytes that recognize their own antigens must die in the process of negative selection.
- Maintenance of cellular homeostasis. Maintaining a certain number of cells and establishing a balance between cellular division and cellular death is crucial. In systems like bone marrow or the digestive system, it is particularly important for the apoptosis processes to work adequately.
- Defense from pathogens. Cells infected by virus or bacteria trigger processes of apoptosis as a defense.
- Defense from the development of tumors. Apoptosis processes also protect us from the development of some types of tumors.